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Formal radical cyclization onto benzene rings--a general method proceeding via cross-conjugated dienones
Derrick L J Clive1, Stephen P Fletcher, Mingzhao Zhu
1Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca
Chemical Communications (Cambridge, England)
|March 18, 2003
Abstract:
Cross-conjugated dienones of type 5 (X = I), which are readily available from phenols, undergo radical cyclization (5 --> 6 --> 7), and the products are easily aromatized (7 --> 8), giving substances that are formally derived by radical cyclization onto a benzene ring (cf. eqn. (1)).