Related Experiment Videos
Warfarin and amoxicillin/clavulanate drug interaction
Liya Davydov1, Marina Yermolnik, Lewis J Cuni
1Department of Pharmacy, St. John's Episcopal Hospital, Far Rockaway, NY, USA. ldavydov@fedeliscare.org.
The Annals of Pharmacotherapy
|March 18, 2003
Summary
This case report highlights a warfarin-amoxicillin/clavulanate potassium interaction causing elevated international normalized ratio (INR) and bleeding. Increased awareness and monitoring are crucial for managing this drug interaction.
Area of Science:
- Pharmacology
- Drug Interactions
- Clinical Medicine
Background:
- Warfarin is a widely used anticoagulant.
- Amoxicillin/clavulanate potassium (AM/CL) is a common antibiotic.
- Drug interactions involving warfarin require careful management.
Observation:
- A case of a 58-year-old woman experiencing elevated INR and hematuria is presented.
- The adverse event was linked to the concurrent use of warfarin and AM/CL.
- This interaction resulted in bleeding complications.
Findings:
- The interaction between warfarin and AM/CL led to a significant increase in INR.
- Microscopic hematuria was observed, indicating bleeding.
- The causality assessment confirmed the possibility of this adverse drug event.
Implications:
- This case underscores the importance of recognizing warfarin-AM/CL interactions.
- Enhanced monitoring of INR levels is essential when these drugs are co-prescribed.
- Preventing bleeding complications requires prompt clinical attention to such interactions.