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Related Experiment Videos

Baroreflex function in vasodepressive syncope: detection of early impairment.

Franco Franchi1, Chiara Lazzeri, Salvatore M Romano

  • 1Department of Internal Medicine, University of Florence School of Medicine, Florence, Italy. f.franchi@dfc.unifi.it

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|March 18, 2003
PubMed
Summary

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Syncopal patients exhibit impaired baroreflex function during head-up tilting, indicating a weaker correlation between blood pressure and heart rate changes. This suggests early detection of baroreflex dysfunction is possible.

Area of Science:

  • Cardiology
  • Physiology
  • Nephrology

Background:

  • Defective baroreflex function is implicated in syncopal episodes.
  • Head-up tilting is a natural stimulus for assessing baroreflex activity.

Purpose of the Study:

  • To assess hemodynamic profile and baroreflex function in syncopal patients versus healthy controls using non-invasive tilting.
  • To evaluate baroreflex-mediated adjustment to postural challenges.

Main Methods:

  • Continuous, non-invasive beat-to-beat monitoring of heart rate and arterial pressure.
  • Calculation of baroreflex function via linear regression slope relating systolic arterial pressure to RR interval changes during tilting phases.

Main Results:

  • Syncopal patients demonstrated significantly weaker correlations between systolic pressure and RR interval changes during both upward (r=0.68) and downward (r=0.48) tilting compared to controls (r=0.91 and r=0.93, respectively).

Related Experiment Videos

  • Impaired baroreflex adjustment was evident even in the early upward tilting phase.

    • Conclusions:

    • Baroreflex impairment in syncopal patients can be detected early during head-up tilting.
    • Non-invasive hemodynamic evaluation during early tilting is useful for identifying abnormal pulse wave contour and related parameters in syncopal patients.