Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Application of bioactive molecules in pulp-capping situations.

M Goldberg1, N Six, F Decup

  • 1Laboratoire de Biologie et Physiopathologie Cranio-faciales, EA 2496, Faculté de Chirurgie Dentaire, Université Paris V, I rue Maurice Arnoux, 92120 Montrouge, France. mgoldod@aol.com

Advances in Dental Research
|March 19, 2003
PubMed
Summary

Bone Sialoprotein (BSP) and Bone Morphogenetic Protein-7 (BMP-7) effectively promote reparative dentin formation in rat molars. These bioactive molecules show superior mineralization compared to calcium hydroxide, offering new dental therapy prospects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accuracy and reliability of tele-ultrasonography in detecting gastrointestinal obstruction in dogs and cats.

The Journal of small animal practice·2023
Same author

Analysis of the dental care queries in the "Mouth-Nose" discussion forum of the French association of patients with Gougerot-Sjögren's syndromes and dryness.

BMC oral health·2022
Same author

Implanted Dental Pulp Cells Fail to Induce Regeneration in Partial Pulpotomies.

Journal of dental research·2017
Same author

Combined brain and anterior visual pathways' MRIs assist in early identification of neuromyelitis optica spectrum disorder at onset of optic neuritis.

Acta neurologica Belgica·2016
Same author

Minimal intervention dentistry II: part 4. Minimal intervention techniques of preparation and adhesive restorations. The contribution of the sono-abrasive techniques.

British dental journal·2014
Same author

Minimal intervention dentistry II: part 2. Management of caries and periodontal risks in general dental practice.

British dental journal·2014

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Research

Background:

  • Pulp capping aims to preserve pulp vitality and promote healing.
  • Bioactive molecules are being investigated for their potential to enhance pulpal wound healing and dentin regeneration.

Purpose of the Study:

  • To evaluate the efficacy of various bioactive molecules in promoting pulpal wound healing and reparative dentin formation in an in vivo rat molar model.

Main Methods:

  • Cavities were prepared in rat upper molars, followed by pulp perforation and pulp capping with different agents.
  • Tested agents included sham controls, a carrier control, calcium hydroxide, Bone Sialoprotein (BSP), Bone Morphogenetic Protein-7 (BMP-7), and N-Acetyl Cysteine (NAC).
  • Histologic and morphometric analyses were performed at 8, 14, and 28 days post-procedure.

Related Experiment Videos

Main Results:

  • BSP demonstrated the highest efficiency in inducing homogeneous, well-mineralized reparative dentin at 28 days.
  • BMP-7 induced osteodentin in the coronal pulp and homogeneous mineralization in the root canal, indicating regional specificity.
  • Both BSP and BMP-7 surpassed calcium hydroxide in mineralization, creating larger mineralized areas with fewer inclusions.
  • Preliminary evidence suggests NAC also promotes reparative dentin formation.

Conclusions:

  • BSP and BMP-7 are highly effective bioactive molecules for inducing reparative dentin formation and mineralization.
  • The findings highlight the potential of BSP and BMP-7 as superior alternatives to calcium hydroxide for pulp capping.
  • Bioactive molecule-based pulp capping presents promising new therapeutic avenues for dental applications.