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Factors affecting left ventricular ejection fraction using automated quantitative gated SPECT.
Isis Gayed1, Emma Cid, Fernando Boccalandero
1Department of Nuclear Medicine, Lyndon B. Johnson General Hospital and M.D. Anderson Cancer Center, Houston, Texas 77030, USA. igayed@di.mdacc.tmc.edu
Clinical Nuclear Medicine
|March 19, 2003
Summary
Automated gated myocardial SPECT accurately calculates left ventricular ejection fraction (LVEF) regardless of defect size. High-dose Tc-99m tetrofosmin SPECT shows improved LVEF accuracy compared to low-dose rest SPECT.
Area of Science:
- Nuclear Cardiology
- Cardiovascular Imaging
- Quantitative Analysis
Background:
- Accuracy of automated quantitative gated SPECT for LVEF needs further investigation in clinical settings.
- Factors like defect size and radiotracer dose require study for LVEF quantification.
Purpose of the Study:
- To assess the impact of myocardial defect size and Tc-99m tetrofosmin dose on LVEF accuracy using automated QGS.
- To compare automated QGS LVEF with echocardiography in patients.
Main Methods:
- 32 patients underwent gated rest/stress SPECT with 8/27 mCi Tc-99m tetrofosmin.
- LVEF calculated using QGS and compared with echocardiography.
- Myocardial defects categorized (scarring, ischemia, mixed) and defect size quantified.
Main Results:
- No significant difference in mean LVEF between high-dose stress QGS, low-dose rest QGS, and echocardiography.
- High-dose stress QGS LVEF correlated better with echocardiography (r=0.86) than low-dose rest QGS (r=0.76).
- Good correlation with echocardiography observed across varying defect sizes in high-dose stress QGS.
Conclusions:
- Myocardial perfusion defects do not compromise LVEF accuracy with automated QGS.
- High-dose gated myocardial SPECT provides more accurate LVEF results compared to echocardiography.