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Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando
Eun-Kyoung Seo1, Dongho Lee, Young Geun Shin
1Chemistry and Life Sciences, Research Triangle Institute, PO Box 12194, Research Triangle Park, North Carolina 27709, USA.
Archives of Pharmacal Research
|March 20, 2003
Abstract:
Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.