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[Inflammation, prelude to renal sclerosis: the importance of NF-kappa B]
Laurent Baud1, Bruno Fouqueray, Agnès Bellocq
1Service d'Explorations Fonctionnelles Multidisciplinaries et Unité INSERM 489, Hôpital Tenon, Paris.
Abstract:
NF-kappa B comprises a family of transcription factors. These are thought to have a central role in the expression of genes involved in cell mobilization, cell proliferation and cell differentiation, and, hence, in inflammation, repair and fibrosis processes. In particular, NF-kappa B activation appears to drive a number of inflammatory diseases of the kidney and their progression to end-stage renal failure. Thus, targeting NF-kappa B activation would lead to the development of new pharmaceutical compounds that would provide novel treatment for these diseases.
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