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[The concept of nephroprotection: toward preventive and curative therapies for renal sclerosis]

Pierre Ronco1

  • 1Unité INSERM 489 et Service de Néphrologie B, Hôpital Tenon, 4 rue de la Chine, 75020 Paris.

Journal De La Societe De Biologie
|March 21, 2003
PubMed

Insights

New strategies target renal fibrosis by inhibiting protein reabsorption, cell transdifferentiation, and inflammation. Research shows renal fibrosis can regress, highlighting therapeutic potential and the need for better biomarkers.

Area of Science:

  • Nephrology
  • Fibrosis Research
  • Molecular Biology

Context:

  • Renal fibrosis is a significant complication of chronic kidney disease.
  • Angiotensin I converting enzyme inhibitors show partial efficacy in preventing renal fibrosis.
  • Emerging research explores novel anti-fibrotic therapeutic avenues.

Purpose:

  • To review novel anti-fibrotic strategies beyond traditional enzyme inhibition.
  • To explore the potential for regression of established renal fibrosis.
  • To identify the need for advanced biomarkers for renal fibrosis staging.

Summary:

  • This review examines advanced anti-fibrotic strategies including inhibiting proximal tubule protein reabsorption, preventing proximal tubule cell transdifferentiation, mitigating angiotensin II and endothelin pro-inflammatory effects, blocking TGF-beta signaling, and addressing renal ischemia.
  • Evidence from experimental models and clinical studies suggests that renal fibrosis may be reversible.
  • The development of new treatments necessitates the identification of reliable urinary and serum markers for different stages of renal fibrosis.

Impact:

  • Provides a comprehensive overview of cutting-edge anti-fibrotic therapies for kidney disease.
  • Highlights the potential for fibrosis regression, offering new hope for patients.
  • Emphasizes the critical need for diagnostic and prognostic biomarkers in managing renal fibrosis.

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