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Related Experiment Videos

Somato-sympathetic vasoconstriction to intranasal fluid administration with consecutive decrease in nasal nitric

B N Landis1, M Beghetti, D R Morel

  • 1ENT Department, University Hospital of Geneva, Switzerland.

Acta Physiologica Scandinavica
|March 22, 2003
PubMed
Summary
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Intranasal saline spray at cool temperatures (22°C) triggers a temporary sympathetic vasoconstriction, reducing nasal nitric oxide (NO) and potentially improving comfort for non-allergic chronic rhinosinusitis patients.

Area of Science:

  • Rhinology
  • Physiology
  • Otolaryngology

Background:

  • Non-allergic chronic rhinosinusitis (NACRS) patients report improved nasal comfort with intranasal saline sprays.
  • Understanding the physiological mechanisms behind this subjective improvement is crucial.

Purpose of the Study:

  • To investigate the physiological effects of intranasal fluid administration on nasal blood flow and nitric oxide (NO) levels.
  • To determine if these effects correlate with the reported comfort in NACRS patients.

Main Methods:

  • Utilized intranasal laser Doppler flowmetry (LDF) to measure nasal blood flow.
  • Measured nasal nitric oxide (NO) variations after administering saline, histamine, N-acetylcysteine (NAC), and lidocaine at 22°C and 37°C.
  • Evaluated the influence of general anesthesia (GA) and adrenaline pre-treatment.

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Main Results:

  • A significant, transient vasoconstriction (14% decrease in LDF) was observed with all substances at 22°C, independent of pharmacological action.
  • This vasoconstriction led to a significant decrease in nasal NO (8.03%).
  • The vasoconstrictive response was abolished by saline at 37°C and adrenaline, but not by GA.

Conclusions:

  • Intranasal fluid nebulization at 22°C induces a sympathetic-mediated vasoconstrictor reflex.
  • This somato-sympathetic response decreases nasal NO levels.
  • These physiological changes may explain the subjective nasal comfort experienced by NACRS patients using saline sprays.