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Published on: December 11, 2017
Bronchoscopic volume reduction with valve implants in patients with severe emphysema
Tudor P Toma1, Nicholas S Hopkinson, James Hillier
1Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
Lancet (London, England)
|March 22, 2003
Summary
Endobronchial valves offer a new lung volume reduction method for severe emphysema patients. This minimally invasive procedure showed significant improvements in lung function and acceptable safety in a pilot study.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Medical Devices
Background:
- Severe emphysema significantly impairs lung function and quality of life.
- Lung volume reduction surgery is an option, but not suitable for all patients.
- Endobronchial valves present a less invasive alternative for lung volume reduction.
Purpose of the Study:
- To evaluate the safety and efficacy of unilateral endobronchial valve insertion for lung volume reduction in severe emphysema.
- To assess functional improvements and regional volume changes post-procedure.
Main Methods:
- Pilot study involving eight patients with severe emphysema.
- Unilateral endobronchial valve insertion.
- Assessment of pulmonary function (FEV1, TLCO) and CT scans before and after intervention.
Main Results:
- Median FEV1 increased by 34% (p=0.028) and median TLCO by 29% (p=0.017).
- CT scans confirmed substantial regional volume reduction in four patients.
- Transient pneumothorax occurred in two patients; no other major adverse events were noted.
Conclusions:
- Unilateral endobronchial valve implantation is a safe and effective method for achieving lung volume reduction in severe emphysema.
- The procedure offers significant functional benefits with acceptable short-term safety.
- This technique provides a viable option for patients unsuitable for or refusing surgery.
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