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Chronic synovitis and HLA B27 in patients with severe haemophilia

Kanjaksha Ghosh1, Umapathy Shankarkumar, Shrimati Shetty

  • 1Institute of Immunohaematology, Floor 13, New Building, KEM Hospital Campus, Parel, 400 012, Mumbai, India.

Lancet (London, England)
|March 22, 2003
PubMed

Insights

A strong association exists between HLA B27 and chronic synovitis in severe haemophilia patients in India. Screening for HLA B27 could aid in preventing this complication.

Area of Science:

  • Immunogenetics
  • Rheumatology
  • Hematology

Background:

  • Chronic synovitis is a complication in severe haemophilia, particularly in India.
  • Ankylosing spondylitis, sharing features with chronic synovitis, is associated with HLA B27.

Purpose of the Study:

  • To investigate the association between HLA B27 and chronic synovitis in Indian patients with severe haemophilia.

Main Methods:

  • A study involving 473 severe haemophilia patients (33 with chronic synovitis) and 1175 healthy controls.
  • Utilized standard serological techniques and the reverse line strip assay for HLA B27 testing.

Main Results:

  • 64% of haemophilia patients with chronic synovitis tested positive for HLA B27.
  • A significantly higher prevalence of HLA B27 was observed in patients with chronic synovitis compared to those without and healthy controls (OR 31.6, p<0.0001).

Conclusions:

  • There is a strong association between HLA B27 and chronic synovitis in Indian patients with severe haemophilia.
  • Screening for HLA B27 in this population may facilitate early treatment and prevention strategies for chronic synovitis.

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