Related Experiment Video
Updated: Sep 26, 2026

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
Published on: May 10, 2022
[Progress in research on heat shock proteins in cardiovascular system]
Jing-Jun Zhou1, Yun-Long Zhu, Jian-Ming Pei
1Department of Physiology, Fourth Military Medical University, Xi'an 710032.
Abstract:
Diverse physiological stresses (e.g., heat shock, ischemia and hemodynamics) produce multiple changes in a cell that affect metabolic processes and cellular structures. In response, stress proteins are synthesized, and are thought to mediate cytoprotection through biological function as molecular chaperones. Accumulated evidence indicates that HSP70, HSP90, HSP47, HSP32 and HSP27 play an important role during cardiac ischemia, ischemia preconditioning, cardiac hypertrophy and vascular wall injury.
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