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[Perianal leukemic infiltration. Case report].

Paulino Martínez-Hernández-Magro1, Eduardo Villanueva-Sáenz, Rocío Ramírez-Aceves

  • 1Departamento de Cirugía de Colon y Recto, Hospital de Especialidades Centro Médico Nacional Siglo XXI, IMSS, México, D. F. paulinomhm@hotmail.com

Revista De Gastroenterologia De Mexico
|March 26, 2003
PubMed
Summary

Leukemic infiltration of perianal skin is rare and can present as an atypical ulcer. Early diagnosis via biopsy and close monitoring are crucial for managing this condition, especially in acute myeloid leukemia (AML) patients.

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Area of Science:

  • Oncology
  • Dermatology
  • Hematology

Background:

  • Leukemic infiltration of perianal skin (leukemia cutis) is an uncommon manifestation.
  • It can present with varied symptoms including erythema, ulceration, fistula, and abscess.
  • Diagnosis relies on biopsy and hematologic studies, with treatment tailored to disease control.

Observation:

  • A case of a 21-year-old female with acute myeloid leukemia (AML M7) presenting with perianal pain and bleeding.
  • Examination revealed an atypical ulcerated lesion in the perianal region.
  • Biopsy confirmed leukemic infiltration.

Findings:

  • Histopathology confirmed leukemic infiltration as the cause of the atypical ulcerated perianal lesion.
  • The patient received conservative management for the perianal condition.

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  • Prognosis is directly linked to the control of the underlying hematologic malignancy.

    • Implications:

    • Clinicians should maintain a high index of suspicion for leukemic infiltration in patients with anal symptoms, particularly those with a known hematologic malignancy.
    • Prompt diagnosis and appropriate management, guided by hematologic status, are essential.
    • Close surveillance is recommended for patients with suspected or confirmed leukemic perianal infiltration.