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Antimycobacterial pimarane diterpenes from the Fungus Diaporthe sp
Suppamit Dettrakul1, Prasat Kittakoop, Masahiko Isaka
1Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Bioorganic & Medicinal Chemistry Letters
|March 27, 2003
Abstract:
Two new pimarane diterpenes, diaportheins A (1) and B (2), were isolated from a culture broth of the fungus Diaporthe sp. BCC 6140. Diaporthein B (2) strongly inhibited the growth of Mycobacterium tuberculosis with the MIC value of 3.1 microg/mL, while diaporthein A (1) showed only mild activity (MIC value of 200 microg/mL).