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Published on: December 5, 2020
Neodolastane diterpenoids from cultures of basidiomycete hydropus cf. trichoderma
Arunrat Yangchum1, Thapanee Pruksatrakul1, Malipan Sappan1
1National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
None:
A highly conjugated 17-nor-neodolastane diterpenoid possessing a nitrile group, hydropusin A (1), and a neodolastane, hydropusin B (2a/2 b/2c), were isolated from cultures of the basidiomycete Hydropus cf. Trichoderma TBRC-BCC 43790. Hydropusin B was isolated as a mixture of three forms of interconvertible isomerization, which was supported by a deuteration experiment. Hydropusin A exhibited weak cytotoxicity to NCI-H187 and Vero cell-lines (IC50 60.6 and 64.5 μM, respectively), whereas hydropusin B showed antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC 12.5 μg/mL).
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Antifungal Agents
Fungal Phylum Basidiomycota
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Fungal Group Zygomycota

