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Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists
Mark A Youngman1, John R Carson, Jung S Lee
1Johnson & Johnson Pharmaceutical Research and Development, Welsh & McKean Roads, PO Box 776, Spring House, PA 19477-0776, USA.
Bioorganic & Medicinal Chemistry Letters
|March 27, 2003
Abstract:
The synthesis and structure-activity relationships of a novel series of aroylpyrrole alkylamides as potent selective bradykinin B(2) receptor antagonists are described. Several members of this series display nanomolar affinity at the B(2) receptor and show activity in an animal model of antinociception.