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Cannabinoids acting on CB1 receptors decrease contractile performance in human atrial muscle.

Andreas Bonz1, Martin Laser, Sina Küllmer

  • 1Medizinische Klinik, Abteilung für Herz und Thoraxchirurgie der Universität Würzburg, Würzburg, Germany.

Journal of Cardiovascular Pharmacology
|March 27, 2003
PubMed
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Cannabinoids like anandamide reduce human atrial muscle contractility through CB(1) receptors. This study confirms CB(1) receptor presence and function in human heart tissue.

Area of Science:

  • Cardiovascular Pharmacology
  • Cannabinoid Receptor Research
  • Human Electrophysiology

Background:

  • Cannabinoids are known to cause hypotension, primarily through CB(1) receptor activation.
  • The cardiovascular effects of cannabinoids are complex and not fully understood.
  • The specific impact of cannabinoids on human heart muscle contractility remains uninvestigated.

Purpose of the Study:

  • To investigate the effects of cannabinoids on human atrial heart muscle contractility.
  • To determine the role of CB(1) receptors in mediating these effects.
  • To confirm the presence of CB(1) receptors in human atrial tissue.

Main Methods:

  • Isolated human atrial muscle preparations were electrically stimulated to contract isometrically.

Related Experiment Videos

  • Preparations were challenged with anandamide, R-methanandamide, and HU-210.
  • Effects were assessed in the presence of selective CB(1) and CB(2) receptor antagonists, and enzyme inhibitors.

    • Main Results:

    • Anandamide, R-methanandamide, and HU-210 significantly decreased systolic force in human atrial muscle.
    • The CB(1) receptor antagonist AM-251 blocked the negative inotropic effect of anandamide.
    • Western blot and immunofluorescence confirmed CB(1) receptor expression in human atrial tissue.

    Conclusions:

    • Endogenous and synthetic cannabinoids decrease contractile performance in human atrial muscle.
    • This effect is mediated via activation of CB(1) receptors located on human heart muscle.
    • The findings reveal a direct impact of cannabinoids on human cardiac contractility.