Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Photoremovable protecting groups: reaction mechanisms and applications.

Anna Paola Pelliccioli1, Jakob Wirz

  • 1Institut für Physikalische Chemie, Universität Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
|March 28, 2003
PubMed
Summary

Photolabile protecting groups, known as caged compounds, allow scientists to control the release of bioactive molecules in living systems. Further development of these photoactivatable bioagents is crucial for advancing biological research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution of Novartis' Small Molecule Screening Deck Design.

Journal of medicinal chemistry·2020
Same author

2-Nitrobenzylarsonium Compounds That Photorelease Heavy-Atom Cholinergic Ligands for Time-Resolved Crystallographic Studies on Cholinesterases.

Angewandte Chemie (International ed. in English)·2018
Same author

Azobenzene photoisomerization quantum yields in methanol redetermined.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2017
Same author

The absorption spectrum of cis-azobenzene.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2017
Same author

Photochemistry of rose bengal in water and acetonitrile: a comprehensive kinetic analysis.

Physical chemistry chemical physics : PCCP·2016
Same author

Searching for Improved Photoreleasing Abilities of Organic Molecules.

Accounts of chemical research·2015

Area of Science:

  • Biochemistry
  • Photochemistry
  • Neuroscience

Background:

  • Photolabile protecting groups are essential for controlling the release of bioactive compounds in biological research.
  • Caged compounds (photoactivatable bioagents) are widely used to investigate chemical signaling events in cell biology and neuroscience.
  • Current applications highlight the need for novel photoremovable protecting groups.

Purpose of the Study:

  • To review the current state and future potential of photolabile protecting groups in biological applications.
  • To emphasize the ongoing need for developing new photoremovable protecting groups to meet diverse research demands.

Main Methods:

  • Review of existing literature on photolabile protecting groups and caged compounds.
  • Discussion of the challenges and requirements for developing new photoremovable protecting groups.

Related Experiment Videos

Main Results:

  • Caged compounds are a valuable tool in biochemistry, cell biology, and neuroscience.
  • The development of photoremovable protecting groups is an active area of photochemical research.
  • New applications require advanced photoremovable protecting groups with specific properties.

Conclusions:

  • Photolabile protecting groups offer significant control over bioactive compound release in living tissues.
  • Continued innovation in photochemistry is necessary to expand the utility of caged compounds in biological studies.
  • Meeting the diverse requirements of future applications presents a significant challenge for photochemists.