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Protein database of Caenorhabditis elegans
Hiroyuki Kaji1, Toshiaki Isobe
1Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-osawa 1-1, Hachioji, Tokyo 192-0397, Japan.
Summary
Whole genome sequencing of Caenorhabditis elegans reveals many gene products. Proteomic research, including liquid chromatography, is crucial for understanding gene function and protein information in this model organism.
Area of Science:
- Genomics
- Proteomics
- Molecular Biology
Background:
- Whole genome sequencing of Caenorhabditis elegans is a landmark achievement.
- Understanding the function of all gene products is a key challenge in modern biology.
- Genome-wide research on C. elegans is ongoing and data is publicly available.
Purpose of the Study:
- To characterize and link gene products to their functions.
- To provide comprehensive information on worm proteins.
- To advance high-throughput proteome analysis.
Main Methods:
- Whole genome sequencing
- Proteomic research
- Liquid chromatography (LC)-based technologies
- 2-dimensional gel electrophoresis
Main Results:
- Identification of numerous known and unknown gene products.
- Application of proteomic research to link sequence and function.
- Advancement of large-scale protein analysis techniques.
Conclusions:
- Characterizing gene products and their functions is essential for biological understanding.
- Proteomic approaches, particularly LC-based methods, are vital for comprehensive protein analysis in C. elegans.
- Continued research is needed to fully elucidate the worm's proteome.