Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteomics of Staphylococcus aureus--current state and future challenges.

Michael Hecker1, Susanne Engelmann, Stuart J Cordwell

  • 1Institut für Mikrobiologie Jahnstrasse 15, D-17487 Greifswald, Germany. hacker@biologie.uni-greifswald.de

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
|March 28, 2003
PubMed
Summary

This review explores Staphylococcus aureus proteomics, highlighting its role in understanding bacterial physiology and antibiotic resistance. Proteomics offers insights into cellular responses and pathogenicity, aiding in developing new diagnostics and treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Personality Traits and Their Association With Medication Non-Adherence in Patients With Multiple Sclerosis.

CNS neuroscience & therapeutics·2026
Same author

Polypharmacy, Potential Drug-Drug Interactions and Medication Non-Adherence in Patients with Multiple Sclerosis: A Longitudinal Study.

Neurology and therapy·2026
Same author

Bayes at the Bedside: Biomarkers in Situations of Clinical Uncertainty.

Diagnostics (Basel, Switzerland)·2026
Same author

Concerns regarding the 2024 revisions of the McDonald criteria for diagnosis of multiple sclerosis.

The Lancet. Neurology·2026
Same author

Uncovering bacterial pseudaminylation with pan-specific antibody tools.

Nature chemical biology·2026
Same author

Cost patterns of long-term prescribed medications in patients with multiple sclerosis in Germany.

Scientific reports·2025

Area of Science:

  • Microbiology
  • Proteomics
  • Bacterial Pathogenesis

Background:

  • Staphylococcus aureus is a significant human pathogen with increasing antibiotic resistance.
  • Understanding its physiology and pathogenicity is crucial for public health.
  • The post-genome era for S. aureus, beginning in 2001, is still developing.

Purpose of the Study:

  • To review the proteome of Staphylococcus aureus.
  • To demonstrate the application of proteomics in studying S. aureus physiology.
  • To discuss the potential of proteomics in addressing antibiotic resistance and developing diagnostics.

Main Methods:

  • Proteome reference map creation.
  • Application of proteomic approaches to analyze S. aureus physiology.

Related Experiment Videos

  • Integration of proteomics with DNA array techniques and bioinformatics.

    • Main Results:

    • Proteomics provides insights into metabolism, stress, and starvation responses.
    • Proteomic signatures can predict cellular physiological states.
    • Proteomics aids in analyzing regulons and understanding pathogenicity regulatory networks.

    Conclusions:

    • Proteomics is a powerful tool for comprehensive understanding of S. aureus cell physiology and pathogenicity.
    • Future applications include strain evaluation, antibiotic resistance analysis, and discovery of new targets and diagnostics.
    • Continued application of proteomics, combined with other 'omics' and bioinformatics, will advance S. aureus research.