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[Histopathologic prognostic factors, serum markers and selected molecular biologic factors in ovarian carcinoma]
Objective:
A review of histopathological prognostic factors, serum markers and selected molecular biological factors in ovarian cancer.
Design:
Review.
Setting:
Department of Obstetrics and Gynaecology, Medical Faculty Hradec Králové, Charles University, Prague; Department of Biological and Medical sciences, Pharmaceutical Faculty, Hradec Králové, Charles University, Prague; Department of Clinical Oncology, Medical Faculty Hradec Králové, Charles University, Prague; Bristol-Myers Squibb, Department of Oncology, Prague.
Method:
Discussion about current evidence from literature.
Conclusion:
Except clinical prognostic factors the wide spectrum behaviour of epithelial ovarian cancers is reflected by some histopathological prognostic factors, serum markers and some molecular biological factors. The most important are grade and tumor ploidy, the level of CA 125 and its changes during the treatment, mutations of p53, BRCA 1 and 2.
