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Future of lung cancer treatment

L Petruželka, J Špaček, L Křížová

    Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
    |June 22, 2021
    PubMed

    Insights

    Lung cancer treatment has evolved from chemotherapy to targeted therapies and immunotherapy, significantly improving survival for advanced non-small cell lung cancer (NSCLC) patients. Next-generation sequencing panels are now standard for NSCLC diagnosis.

    Area of Science:

    • Oncology
    • Genomics
    • Pharmacology

    Background:

    • Lung cancer treatment has historically relied on non-targeted cytostatic therapies.
    • Recent advancements have shifted the paradigm towards precision medicine.
    • The development of novel drugs has been crucial in this evolution.

    Purpose of the Study:

    • To highlight the evolution of lung cancer treatment strategies.
    • To emphasize the impact of targeted therapy and immunotherapy in non-small cell lung cancer (NSCLC).
    • To underscore the importance of genomic profiling in modern oncology.

    Main Methods:

    • Review of historical and recent advancements in NSCLC systemic treatment.
    • Analysis of the transition from traditional chemotherapy to targeted agents and immunotherapies.
    • Incorporation of European Society for Medical Oncology (ESMO) recommendations.

    Main Results:

    • Targeted therapies and immunotherapies, including checkpoint inhibitors, have led to significant survival improvements in advanced NSCLC.
    • Genomic profiling has become integral to personalized cancer treatment.
    • The development of innovative drugs targeting specific molecular structures shows great promise.

    Conclusions:

    • The evolution of NSCLC treatment exemplifies a successful shift towards precise, genomically-guided therapies.
    • Targeted therapy and immunotherapy represent a breakthrough in managing advanced NSCLC.
    • Next-generation sequencing panel testing is recommended as a standard diagnostic approach for NSCLC.
    Keywords:
    agnostic tumor therapy –next-generation sequencingcheckpoint inhibitorsnext generation sequencingpersonalized medicineprecision medicinetargeted therapy

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