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Two new carbazole alkaloids from Murraya koenigii
Yun-Song Wang1, Hong-Ping He, Yue-Mao Shen
1The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, People's Republic of China.
Abstract:
Two new carbazole alkaloids named murrayanine (1) and 8,8' '-biskoenigine (2) were isolated from Murraya koenigii. The structure elucidations for 1 and 2 were carried out on the basis of 1D and 2D NMR experiments. Compound 1 was a novel carbazole alkaloid with a rare phenylpropanyl substitution. Compound 2 was a symmetrical dimer of the carbazole alkaloid koenigine and showed antiosteoporotic activity in the CAT-B model with IC(50) 1.3 microg/mL. The synthesis of 2 from koenigine was carried out through oxidative coupling using a solid state reaction.