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Sporozoites of Eimeria acervulina within intestinal macrophages in normal experimental infections: an ultrastructural

E Michael

    Zeitschrift Fur Parasitenkunde (Berlin, Germany)
    |March 31, 1976
    PubMed

    Insights

    Eimeria acervulina sporozoites survive within intestinal macrophages, altering host cell structures. These findings shed light on parasite survival and transport mechanisms within the host.

    Area of Science:

    • Veterinary Parasitology
    • Cell Biology
    • Immunology

    Background:

    • Eimeria acervulina is a significant poultry pathogen.
    • Understanding parasite-host interactions is crucial for disease control.

    Purpose of the Study:

    • To investigate the fate and host cell modifications of Eimeria acervulina sporozoites within intestinal macrophages.

    Main Methods:

    • Light and electron microscopy were used to examine infected intestinal tissues.
    • Structural analysis of both parasite and host cells was performed.

    Main Results:

    • Sporozoites were identified within macrophages 5-6 days post-infection, residing in intact parasitophorous vacuoles.
    • Macrophages exhibited significant structural changes, including lysosome absence and organelle proliferation (Golgi, endoplasmic reticulum).
    • Sporozoites appeared structurally normal with no signs of development within the macrophages.

    Conclusions:

    • Macrophages can harbor Eimeria acervulina sporozoites without apparent immediate degradation.
    • Host cell alterations suggest a complex interaction potentially facilitating parasite survival and subsequent development or transport.
    • Further research is needed to elucidate the precise mechanisms of sporozoite survival and dissemination.

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