Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Secretory granule exocytosis.

Robert D Burgoyne1, Alan Morgan

  • 1The Physiological Laboratory, University of Liverpool, United Kingdom. burgoyne@liverpool.ac.uk

Physiological Reviews
|March 29, 2003
PubMed
Summary

Regulated exocytosis, crucial for cell communication, shares core machinery across diverse cell types like neurons and endocrine cells. Variations in control mechanisms adapt this process for specific physiological roles.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional analysis of epilepsy-associated GABA<sub>A</sub> receptor mutations using Caenorhabditis elegans.

Epilepsia open·2024
Same author

Tissue distribution of cysteine string protein/DNAJC5 in C. elegans analysed by CRISPR/Cas9-mediated tagging of endogenous DNJ-14.

Cell and tissue research·2024
Same author

A Caenorhabditis elegans model of autosomal dominant adult-onset neuronal ceroid lipofuscinosis identifies ethosuximide as a potential therapeutic.

Human molecular genetics·2022
Same author

Lysosome exocytosis is required for mitosis in mammalian cells.

Biochemical and biophysical research communications·2022
Same author

Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease.

Brain communications·2022
Same author

Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension.

The Biochemical journal·2021

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Physiology

Background:

  • Regulated exocytosis is fundamental for cellular secretion in various cell types, including neurons, endocrine, exocrine, and hemopoietic cells.
  • Secretory granule exocytosis shares common mechanisms and protein components with synaptic vesicle exocytosis.
  • Despite conserved machinery, distinct regulatory variations exist, tailored to the specialized functions of different cell types.

Purpose of the Study:

  • To review the diverse cell types exhibiting regulated secretory granule exocytosis.
  • To assess the presence of conserved exocytotic fusion machinery in these cells.
  • To compare regulatory mechanisms specific to secretory granules versus synaptic vesicles and across different cell types.

Main Methods:

  • Literature review of studies on regulated exocytosis.
  • Analysis of conserved exocytotic machinery components.
  • Comparative assessment of regulatory signals and accessory control mechanisms.

Main Results:

  • Regulated exocytosis is a conserved process observed across a wide spectrum of cell types.
  • The core protein machinery for exocytosis is widely expressed and conserved.
  • Significant variations in regulatory signals and accessory mechanisms fine-tune exocytosis for specific cell functions.

Conclusions:

  • The fundamental machinery for regulated exocytosis is conserved across many cell types.
  • Cell-specific accessory mechanisms provide diverse controls over the core exocytotic process.
  • Understanding these variations is key to comprehending specialized cellular secretion.

Related Experiment Videos