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Related Experiment Videos

Do leukotrienes increase cell viability in human intestinal epithelial cells?

John F Ohd1, Katarina Wikström, Anita Sjölander

  • 1Department of Laboratory Medicine, Division of Experimental Pathology, Lund University, Malmö General Hospital, Entrance 78, Malmö, SE-205 02 Sweden.

Advances in Experimental Medicine and Biology
|April 1, 2003
PubMed
Summary

Leukotrienes enhance intestinal epithelial cell viability. Leukotriene B4 (LTB4) also reverses cell death signs caused by the COX-2 inhibitor NS-398, suggesting a protective role.

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Area of Science:

  • Cell biology
  • Gastroenterology
  • Inflammation research

Background:

  • Intestinal epithelial cells form a critical barrier.
  • Non-necrotic cell death can impair barrier function.
  • Leukotrienes (LTs) are inflammatory mediators.

Purpose of the Study:

  • To investigate the role of leukotrienes in intestinal epithelial cell viability.
  • To determine if LTB4 affects cell death induced by COX-2 inhibition.

Main Methods:

  • Human intestinal epithelial cells were treated with leukotrienes.
  • Cells were exposed to the COX-2 inhibitor NS-398.
  • Cell viability and morphology were assessed.

Main Results:

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  • Leukotrienes increased baseline cell viability.
  • LTB4 partially reversed morphological changes of non-necrotic cell death induced by NS-398.

    • Conclusions:

    • Leukotrienes may play a protective role in intestinal epithelial cells.
    • LTB4 could counteract specific forms of cell death in the intestine.