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Published on: June 2, 2023
Do leukotrienes increase cell viability in human intestinal epithelial cells?
John F Ohd1, Katarina Wikström, Anita Sjölander
1Department of Laboratory Medicine, Division of Experimental Pathology, Lund University, Malmö General Hospital, Entrance 78, Malmö, SE-205 02 Sweden.
Abstract:
In this preliminary report we present data showing that leukotrienes increase the baseline cell viability in human intestinal epithelial cells and that LTB4 partially reverses the morphological hallmarks of non-necrotic cell death induced by the COX-2 specific inhibitor NS-398. The proposed signaling mechanisms regulating these events are summarized in fig. 3. Please view the work on LT signal transduction in these cells by Thodeti et al. in this volume.
