Related Experiment Video

Updated: Sep 26, 2026

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment
10:59

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Published on: November 23, 2017

The regulation of cyclooxygenase-1 and -2 in knockout cells and mice

Leslie R Ballou1

  • 1Department of Veterans Affairs Medical Center, Departments of Medicine and Biochemistry, University of Tennessee, Memphis, TN 38104, USA.

Advances in Experimental Medicine and Biology
|April 1, 2003
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer
11:53

A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer

Published on: July 12, 2017

Related Experiment Videos

Last Updated: Sep 26, 2026

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment
10:59

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Published on: November 23, 2017

A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer
11:53

A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer

Published on: July 12, 2017

Related Concept Videos

In-vitro Mutagenesis (Gene Knockouts)02:29

In-vitro Mutagenesis (Gene Knockouts)

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

Articles linked to this work by shared authors, journal, and citation graph.

Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant.

Prostaglandins & other lipid mediators·2007

Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin.

American journal of physiology. Heart and circulatory physiology·2006

LPS-activated complement, not LPS per se, triggers the early release of PGE2 by Kupffer cells.

American journal of physiology. Regulatory, integrative and comparative physiology·2005

Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections.

American journal of physiology. Renal physiology·2005

Cyclooxygenase isoenzymes and patency of ductus arteriosus.

Prostaglandins, leukotrienes, and essential fatty acids·2005

Nociception and the differential expression of cyclooxygenase-1 (COX-1), the COX-1 variant retaining intron-1 (COX-1v), and COX-2 in mouse dorsal root ganglia (DRG).

Prostaglandins & other lipid mediators·2004

The Emergent Architecture of Autonomous Clocks Described by Computational Algorithms of Regulatory Networks.

Advances in experimental medicine and biology·2026

Physical Frameworks and Theories on How Autonomous Biological Oscillators Synchronize.

Advances in experimental medicine and biology·2026

Leveraging Autonomous Biological Oscillators for Directed Evolution of Switchable Proteins.

Advances in experimental medicine and biology·2026

Synthetic Cell-Based Approaches to Dissect Autonomous Cellular Oscillators: Recent Applications on the Cell Cycle.

Advances in experimental medicine and biology·2026

Autonomous Oscillations of NF-κB.

Advances in experimental medicine and biology·2026

An Autonomous Clock that Controls Genetic Information Flow and Cellular Proteostasis.

Advances in experimental medicine and biology·2026

Sacituzumab govitecan in metastatic breast cancer: a systematic review and meta-analysis of its clinical benefit and safety.

Frontiers in medicine·2026

Nerandomilast is Associated With Altered Alveolar Epithelial Cell State Dynamics While Attenuating Fibrotic Remodeling in Pulmonary Fibrosis.

Genes to cells : devoted to molecular & cellular mechanisms·2026

Inhibition of the NR4A1-mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity.

British journal of pharmacology·2026

Inhibition of ROR1 signaling with zilovertamab plus ibrutinib in chronic lymphocytic leukemia: safety, mechanistic insights, and an exploratory signal in del(17p) disease.

Leukemia·2026

Integrated morphological and transcriptomic analysis of bone disorders in aldosterone-salt hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension·2026

TFAM loss drives oxaliplatin resistance by linking mtDNA release to STING-TBK1-mediated lysophagy.

Oncogene·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us