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Updated: Aug 21, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Late-onset bacteria endophthalmitis following glaucoma drainage implantation
Brian A Francis1, David A DiLoreto, Lawrence P Chong
1Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA.
Abstract:
A clinicopathologic report of late-onset bacterial endophthalmitis 4 years after implantation of a Baerveldt drainage implant is described. An 80-year-old woman with glaucoma presented 8 years after tube shunt implantation with clinical endophthalmitis. During surgical removal of the implant, a small conjunctival buttonhole caused by the suture securing the plate to the sclera was noted to be the only entry site. Vitreous and anterior chamber taps were performed with intravitreal antibiotics. Cultures revealed Streptococcus pneumoniae infection. The pathologic analysis showed epithelialization of the conjunctival button-hole and diffuse ocular inflammation, mucopurulent material, and fibrovascular membranes. Due to severe pain, the eye was enudeated after 1 week.
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