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Updated: Sep 3, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Multimodal Imaging Features of Degenerative Retinoschisis
Landon J Rohowetz1, Yale L Fisher1, Sugi Panneerselvam1
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Background And Objective:
Degenerative retinoschisis is an age-related condition characterized by splitting of the neurosensory retina. While the diagnosis is typically made by clinical examination, imaging techniques are useful to further characterize the condition and differentiate it from retinal detachment. The purpose of the current study was to review the imaging features of degenerative retinoschisis and illustrate the multimodal findings in four eyes using contemporary imaging modalities.
Materials And Methods:
This was a retrospective, consecutive case series of patients with degenerative retinoschisis. Clinical notes and multimodal imaging findings were reviewed.
Results:
The study comprised four eyes of two patients with degenerative retinoschisis. Visual acuity and anatomic features on multimodal imaging were stable in all eyes at 6 months or more of follow-up.
Conclusions:
Degenerative retinoschisis is usually asymptomatic and nonprogressive. Emerging technologies allowing potentially more accurate diagnosis in select cases include widefield swept-source optical coherence tomography, high-resolution B-scan, and ultrasound biomicroscopy.
