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Synthesis of vanillin ethers from 4-(bromomethyl) coumarins as anti-inflammatory agents
Manjunath Ghate1, D Manohar, V Kulkarni
1Post Graduate Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India.
European Journal of Medicinal Chemistry
|April 2, 2003
Abstract:
4-(Bromomethyl) coumarins 1 have been reacted with vanillins, 2 and 2A to obtain the corresponding ethers 3 and 5. Ethers 3 have been reacted with ethyl cyanoacetate to obtain the unsaturated esters 4. Ethers 5 have been converted to the corresponding 4-(2'-benzo[b] furanyl) coumarins 6 by an intramolecular aldol condensation. Eight compounds have been screened for their anti-inflammatory activity. Out of these the 5,6-benzo-4-2'-benzo[b]furanyl) coumarin (6c) and the aryloxymethyl coumarin (4) with p-formyl group were found to be most active.