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Updated: Sep 26, 2026

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia
Published on: November 9, 2018
[Expression of beta-amyloid and tau-protein in mastocytes in Alzheimer disease]
I M Kvetnoĭ1, T V Kvetnaia, I Iu Riadnova
1Institute of Bioregulation and Gerontology, North-Western Department, Russian Academy of Medical Sciences, 197110, Saint-Petersburg.
Abstract:
With immunochemical assay, the expression of B-amyloid and tau-protein in the mast cells of the stomach and skin was first detected in patients with Alzheimer's disease (AD), which supports the hypothesis that AD is a systemic disease involving different organs and tissues. Verification of expression of two key peptides that participate in the pathogenesis of AD in the samples of extra-brain tissues allows B-amyloid and tau-protein to be regarded as promising markers and mast cells to be considered to the most suitable object for lifetime diagnosis of neurodegenerative diseases.
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