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Hollow filler-binders as excipients for direct compaction
Gerad K Bolhuis1, Anko C Eissens, Thijl P Adrichem
1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. G.K.Bolhuis@farm.rug.nl
Pharmaceutical Research
|April 3, 2003
Summary
Using hollow inulin particles significantly improves tablet compaction and reduces lubricant sensitivity compared to solid particles. This hollow particle design enhances bonding and tablet strength, overcoming limitations of ductile materials.
Area of Science:
- Materials Science
- Pharmaceutical Technology
Background:
- Ductile materials offer large bonding surfaces during compaction but suffer from high lubricant sensitivity, hindering strong bond formation.
- Inulin, a ductile filler-binder, exhibits good compactibility but its bonding properties decrease significantly with lubricants.
Purpose of the Study:
- To enhance the compactibility and reduce lubricant sensitivity of ductile filler-binders, specifically inulin.
- To investigate the efficacy of using hollow particles instead of solid particles to achieve these improvements.
Main Methods:
- Solid and hollow inulin particles were prepared using spray-drying.
- Tablets were compressed using a compaction simulator, with and without 0.5% magnesium stearate lubricant.
- Tablet crushing strength was measured using a Schleuniger apparatus.
Main Results:
- Solid inulin showed good compactibility without lubricant, but lubrication significantly reduced bonding.
- Hollow inulin particles demonstrated increased compactibility and reduced lubricant sensitivity compared to solid particles.
- Hollow particles fragmented before plastic deformation, leading to higher crushing strength and lower lubricant sensitivity.
Conclusions:
- Employing hollow inulin particles effectively increases compactibility.
- The use of hollow particles significantly decreases lubricant sensitivity in ductile materials like inulin.