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Core structure in roselipins essential for eliciting inhibitory activity against diacylglycerol acyltransferase
Hiroshi Tomoda1, Noriko Tabata, Yukako Ohyama
1Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, Shirokane, Minato-ku, Tokyo 108-8641, Japan. tomoda@lisci.kitasato-u.ac.jp
The Journal of Antibiotics
|April 3, 2003
Abstract:
Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol. Demannosyl and/or dearabinitoyl roselipins were prepared chemically or enzymatically. Demannnosyl roselipins conserved the DGAT inhibitory activity, but the others lost the activity, indicating that the arabinitoyl fatty acid core is essential for eliciting the activity.