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[Simvastatin-induced lichen planus pemphigoides].

P-E Stoebner1, C Michot, C Ligeron

  • 1Service de Dermatologie-Allergologie-Photobiologie, Hôpital Saint-Eloi, 80, avenue Augustin Fliche, 34295 Montpellier Cedex 5. p-stoebner@chu-montpellier.fr

Annales De Dermatologie Et De Venereologie
|April 3, 2003
PubMed
Summary

Simvastatin, a cholesterol-lowering drug, can induce a rare skin condition called lichen planus pemphigoides. Discontinuation of simvastatin led to the resolution of the patient's skin lesions.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Simvastatin is a widely used HMG-CoA reductase inhibitor for treating hyperlipidemia.
  • Drug-induced skin reactions are a known concern with various medications.

Observation:

  • A 63-year-old male developed a bullous, lichenoid eruption after two months of simvastatin treatment.
  • Histopathology and immunofluorescence confirmed lichen planus pemphigoides.
  • Antibodies against BP 180 kDa antigens were detected via Western blot.

Findings:

  • Simvastatin treatment was associated with the onset of lichen planus pemphigoides.
  • Discontinuation of simvastatin resulted in the complete resolution of the skin lesions.
  • This case highlights a potential adverse drug reaction to simvastatin.

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Implications:

  • Clinicians should consider simvastatin as a potential cause of lichen planus pemphigoides in patients presenting with similar symptoms.
  • Awareness of this association is crucial given the increasing use of HMG-CoA reductase inhibitors.
  • Further research may be warranted to elucidate the mechanism of simvastatin-induced lichen planus pemphigoides.