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Related Experiment Videos

Cutaneous histoplasmosis.

J Studdard, W F Sneed, M R Taylor

    The American Review of Respiratory Disease
    |May 11, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Cutaneous lesions are a rare sign of disseminated histoplasmosis, often seen in immunocompromised patients. This case highlights secondary skin involvement in progressive histoplasmosis, emphasizing the need for vigilance in at-risk individuals.

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    Area of Science:

    • Mycology
    • Infectious Diseases
    • Dermatology

    Background:

    • Histoplasmosis is typically a respiratory infection caused by Histoplasma capsulatum.
    • Cutaneous manifestations are uncommon, usually indicating disseminated disease.
    • Progressive disseminated histoplasmosis (PDH) can present with secondary skin lesions.

    Observation:

    • A patient with a history of PDH and amphotericin B treatment presented with new cutaneous lesions.
    • Biopsy and culture confirmed Histoplasma capsulatum in the skin lesions.
    • Literature review identified only 7 previous cases of secondary cutaneous histoplasmosis in 20 years.

    Findings:

    • The patient's cutaneous lesions were positive for Histoplasma capsulatum.
    • All reported cases, including this one, involved patients with compromised immunity or on steroid therapy.

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  • Secondary skin histoplasmosis is a rare but significant finding in PDH.

    • Implications:

    • Cutaneous lesions in patients with known histoplasmosis warrant thorough investigation for dissemination.
    • Immunocompromised status and steroid use are critical risk factors for secondary skin histoplasmosis.
    • Early recognition and treatment are crucial for managing disseminated histoplasmosis with cutaneous involvement.