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Synthesis of alpha,alpha-dibromo esters as precursors of ynolates
Mitsuru Shindo1, Yusuke Sato, Ryoko Koretsune
1Institute for Medicinal Resources, University of Tokushima, 1 Sho-machi, Japan. shindo@ph2.tokushima-u.ac.jp
Chemical & Pharmaceutical Bulletin
|April 4, 2003
Abstract:
Aliphatic alpha,alpha-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium alpha-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. alpha-Trimethylsilyl-alpha,alpha-dibromo esters were synthesized via radical bromination.