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Updated: Sep 24, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Pd-catalyzed cascade γ-C(sp3)-H activation/cyclization of aliphatic amines with allyl electrophiles: access to
Anita Sahoo1, Madhab Barman1, Priya Patra1
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, India. tpunni@iitg.ac.in.
Abstract:
Sequential Pd-catalyzed auxiliary-assisted γ-C(sp3)-H alkenylation and cyclization of N-protected amines with allyl electrophiles has been accomplished to furnish optically active δ-vinyl pyrrolidines that are privileged cores in diverse bioactive molecules and natural products. The diastereoselectivity, functional group diversity and late-stage modifications of the natural products are the important practical features.
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