Thrombohaemorrhagic balance in diabetes mellitus

Diabetes changes the thrombohaemorrhagic balance which exists in healthy flowing blood. This change predisposes a diabetic patient to various thrombo-embolic conditions, leading to increased mortality and morbidity of these patients. Increase in certain coagulation factors like factors XII, XI, VIII, fibrinogen and VWF, decreased fibrinolysis, increased platelet aggregation, endothelial cell dysfunction coupled with increased blood viscosity and decreased red cell deformability are some of the changes that contribute to increased thrombo-embolic incidence in this disease.