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Stevens-Johnson syndrome from ophthalmic sulfonamide
Archives of Dermatology
|April 1, 1976
Summary
A rare case of Stevens-Johnson syndrome occurred in a patient using ophthalmic sulfacetamide sodium eye drops. This highlights the risk of sulfonamide-induced severe cutaneous adverse reactions, even with topical application.
Area of Science:
- Ophthalmology
- Dermatology
- Pharmacology
Background:
- Sulfonamides are known triggers for severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and erythema multiforme (EM).
- Previous sulfonamide exposure can increase the risk of subsequent reactions.
Observation:
- A 71-year-old male with a history of bullous drug reaction to a sulfonamide developed Stevens-Johnson syndrome.
- The patient was treated with ophthalmic sulfacetamide sodium, a sulfonamide-containing eye drop, for one day.
Findings:
- This case represents the first reported instance of Stevens-Johnson syndrome attributed to ophthalmic sulfonamide use.
- The findings underscore that even topical sulfonamide preparations can precipitate severe drug reactions.
Implications:
- Ophthalmologists and healthcare providers should be aware of the potential for SCARs from ophthalmic sulfonamides.
- Patients with a history of sulfonamide sensitivity should be carefully evaluated before initiating treatment with ophthalmic sulfonamides.
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