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[Brain irradiation and phenytoin: a dangerous liaison?]
C Camartin1, W H Reinhart, M Kuhn
1Departement Innere Medizin, Kantonsspital Chur.
Praxis
|April 5, 2003
Abstract:
Three patients are presented, who developed a severe skin reaction after brain-irradiation and concomitant phenytoin treatment. A fourth patient from the databAse of the Swiss Drug Monitoring Center, showed a Stevens-Johnson-Syndrome after a severe electric shock and phenytoin treatment. Possible pathogenic mechanisms of these life-threatening complications and possible alternatives to the phenytoin treatment in irradiated patients are discussed.