Related Experiment Videos
Deep vein thrombosis and systemic inflammatory response: a pilot trial
Markus Reiter1, Robert A Bucek, Nihat Koca
1Department of Angiology, University Clinic, General Hospital, Vienna, Austria. markus.reiter@akh-wien.ac.at
Wiener Klinische Wochenschrift
|April 5, 2003
Summary
Deep vein thrombosis (DVT) triggers a systemic inflammatory response. This study found significantly elevated white blood cell counts and C-reactive protein levels in patients diagnosed with DVT.
Area of Science:
- Vascular Medicine
- Inflammation Research
- Diagnostic Biomarkers
Background:
- Deep vein thrombosis (DVT) symptoms like swelling and pain suggest an inflammatory component.
- A prospective pilot trial was conducted to investigate a potential systemic inflammatory response in DVT patients.
Purpose of the Study:
- To determine if deep vein thrombosis induces a systemic inflammatory response.
- To assess white blood cell count and C-reactive protein levels in suspected DVT cases.
Main Methods:
- 100 consecutive patients with suspected deep vein thrombosis (DVT) were enrolled.
- White blood cell count and plasma C-reactive protein were measured.
- Duplex sonography or ascending venography confirmed DVT diagnosis.
Main Results:
- Deep vein thrombosis (DVT) was diagnosed in 37% of patients.
- Significantly elevated white blood cell count (P = 0.012) and C-reactive protein (P < 0.001) were observed in DVT patients.
- No correlation was found between inflammatory markers and thrombotic burden or symptom duration.
Conclusions:
- Thrombus formation and vein wall damage in DVT initiate a systemic inflammatory reaction.
- Elevated white blood cell and C-reactive protein levels are indicators of this inflammatory response in DVT.