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Updated: Jul 22, 2026

Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
[Efficacy of integrated backscatter imaging by acoustic densitometry for identifying ultrasonic tissue
Susumu Nishikawa1, Shuji Katoh, Hiroki Takada
1Division of Cardiovascular Medicine, Murakami Memorial Hospital, Asahi University, Hashimoto-cho 3-23, Gifu, Gifu 500-8523.
Insights
Acoustic densitometry and contrast echocardiography can differentiate left ventricular apical thrombus from papillary muscle. This ultrasonic tissue characterization method aids in accurate diagnosis.
Area of Science:
- Cardiovascular Imaging
- Diagnostic Ultrasound
- Medical Technology
Background:
- Distinguishing between left ventricular apical thrombus and papillary muscle is crucial for patient management.
- Echocardiography is a primary tool for cardiac imaging, but differentiating certain lesions can be challenging.
Observation:
- Two cases presented with high echoic lesions in the left ventricle apex.
- Acoustic densitometry revealed lower integrated backscattering amplitude in Case 1 (thrombus) compared to myocardium.
- Contrast echocardiography showed a perfusion defect in Case 1 but not in Case 2.
Findings:
- The high echoic lesion in Case 1 was identified as thrombus, while in Case 2 it was identified as papillary muscle.
- Contrast echocardiography time-intensity curve analysis demonstrated distinct amplitude patterns for thrombus versus myocardium.
- Ultrasonic tissue characterization using these methods proved effective for differentiating the lesions.
Implications:
- This technique enhances the diagnostic accuracy of echocardiography for apical cardiac lesions.
- Improved differentiation can lead to more appropriate treatment strategies for patients with left ventricular abnormalities.
- The study highlights the utility of advanced echocardiographic techniques in clinical practice.
Abstract:
Echocardiography demonstrated a high echoic lesion(6 x 5 mm) in the apex of the left ventricle of a 72-year-old man(Case 1) and similar lesions(7 x 6 mm and 4 x 3 mm) in the apex of the left ventricle of a 60-year-old man(Case 2). The amplitude of cyclic variation of integrated backscattering of the high echoic lesions was measured by acoustic densitometry to be lower than that of the myocardium in Case 1, but similar to that of the myocardium in Case 2. Contrast echocardiography detected the perfusion defect of the high echoic lesion in Case 1, but not in Case 2 in the apical four-chamber view. These findings showed that the high echoic lesion indicated thrombus in Case 1, and papillary muscle in Case 2. Measurement of the amplitude of the time intensity curve with contrast echocardiography showed that the amplitude of thrombus was different from that of myocardium. This method is useful for ultrasonic tissue characterization.
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