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Central neurocytoma with craniospinal dissemination
Hidemasa Takao1, Keiichi Nakagawa, Kuni Ohtomo
1Department of Radiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. takaoh-tky@umin.ac.jp
Journal of Neuro-Oncology
|April 5, 2003
Summary
Central neurocytoma, a rare brain tumor, can disseminate throughout the central nervous system. This case highlights treatment strategies for disseminated central neurocytoma with a high MIB-1 labeling index.
Area of Science:
- Neuro-oncology
- Central Nervous System Tumors
- Neurosurgery
Background:
- Central neurocytoma is a rare, typically benign central nervous system tumor, often found in the lateral ventricles.
- While generally benign, some central neurocytoma cases exhibit recurrence or rare craniospinal dissemination.
- Histological atypia is uncommon in disseminated cases, but a high MIB-1 labeling index (MIB-1 LI) is frequently observed.
Observation:
- This report details a central neurocytoma case with craniospinal dissemination, a rare event affecting only seven individuals previously.
- The patient presented with a high MIB-1 LI of 4.6%, indicating rapid cell proliferation.
- Dissemination extended from the lateral ventricles to the spinal cord at the T4 level.
Findings:
- The patient underwent partial tumor resection followed by radiation therapy for residual tumor and disseminated disease.
- Post-radiation treatment resulted in a decrease in tumor size.
- This case adds to the limited understanding of disseminated central neurocytoma, particularly those with high MIB-1 LI.
Implications:
- This case provides valuable insights into managing disseminated central neurocytoma, especially when characterized by a high MIB-1 LI.
- The findings may inform treatment strategies and prognostication for similar rare and aggressive presentations of central neurocytoma.
- Further research into the behavior and treatment of disseminated central neurocytoma is warranted.