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Updated: Sep 26, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
Published on: June 14, 2016
RAS and connective tissue in the heart
1Department of Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Rm. 353 Dobbs Research Institute, 951 Court Avenue, Memphis, TN 38163, USA.
Abstract:
Circulating angiotensin (Ang) II has well-known endocrine properties in the cardiovasculature. AngII, produced de novo within the heart, has various autocrine and paracrine properties on resident cells expressed via AT(1) receptor-ligand binding. Herein, we review the heart's renin-angiotensin system and its role in connective tissue turnover involving heart valve leaflets and fibrous tissue that appears at sites of injury, such as following myocardial infarction.
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