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An update on renal peptide transporters
Hannelore Daniel1, Isabel Rubio-Aliaga
1Molecular Nutrition Unit, Technical University of Munich, D-85350 Freising-Weihenstephan, Germany. daniel@wzw.tum.de
American Journal of Physiology. Renal Physiology
|April 5, 2003
Summary
Renal epithelial cells utilize PEPT1 and PEPT2 peptide transporters for di- and tripeptide uptake. These proton-dependent carriers exhibit distinct expression patterns and transport various peptides and drugs in the kidney.
Area of Science:
- Biochemistry
- Molecular Biology
- Renal Physiology
Background:
- Renal epithelial cells possess brush-border membrane transporters PEPT1 and PEPT2.
- These transporters are crucial for the uptake of short-chain peptides.
Purpose of the Study:
- To review postcloning research on the molecular physiology of renal peptide transport.
- To summarize data on genes, protein structures, and functions of PEPT1 and PEPT2.
Main Methods:
- Review of postcloning research literature.
- Analysis of studies in heterologous expression systems.
Main Results:
- PEPT1 and PEPT2 show distinct surface expression patterns along the proximal tubule.
- PEPT1 has low affinity/high capacity; PEPT2 has high affinity/low capacity.
- Both transporters facilitate proton-dependent electrogenic cotransport of diverse di- and tripeptides and related drugs.
Conclusions:
- PEPT1 and PEPT2 play distinct yet complementary roles in renal peptide and drug transport.
- Understanding their molecular physiology is key to renal drug delivery and peptide handling.