Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Time-dependent changes in cyclosporine exposure: implications for achieving target concentrations.

Claudia Rosso Felipe1, Helio Tedesco Silva, Paula Goulart Pinheiro Machado

  • 1Nephrology Division, Hospital do Rim e Hipertensão, Universidade Federal de São Paulo, SP 04038-002, São Paulo, Brazil.

Transplant International : Official Journal of the European Society for Organ Transplantation
|April 5, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effect of Adding Dapagliflozin on Chronic Renal Allograft Dysfunction: A Randomized, Prospective, Double-blind, Placebo-controlled Trial.

Transplantation·2026
Same author

The APOL1 gene and kidney transplantation: a review article.

Jornal brasileiro de nefrologia·2026
Same author

Effects of dialysis therapies on circulating levels of endothelial markers after kidney transplant in children: focus on positive aspect of peritoneal dialysis.

Clinical and experimental nephrology·2025
Same author

Critically Important Cancer Outcomes to Report in Kidney Transplant Trials.

Kidney international reports·2025
Same author

HNA-3 antibodies and increased risk of recurrent rejection in kidney transplant recipients.

Human immunology·2025
Same author

Commentary to "Robotically procured living donor kidneys transplanted into pediatric recipients".

Journal of pediatric urology·2025

Early kidney transplant recipients require higher cyclosporine doses and more frequent adjustments. Cyclosporine exposure significantly increases within the first month post-transplant, necessitating careful monitoring for optimal immunosuppression.

Area of Science:

  • Nephrology
  • Pharmacokinetics
  • Transplantation Immunology

Background:

  • Cyclosporine is a cornerstone of immunosuppression after kidney transplantation.
  • Understanding early cyclosporine pharmacokinetics is crucial for preventing rejection and optimizing patient outcomes.

Purpose of the Study:

  • To analyze early changes in trough blood cyclosporine concentrations and exposure after kidney transplantation.
  • To identify optimal monitoring strategies for cyclosporine therapy in the early post-transplant period.

Main Methods:

  • Seventy-two kidney transplant recipients on cyclosporine-based therapy were monitored.
  • Pharmacokinetic studies were conducted at day 4, and months 2, 3, and 6 post-transplantation.
  • Trough concentrations (C0) and other exposure parameters (Cmax, AUC, Cavg, C12) were assessed.

Related Experiment Videos

Main Results:

  • Dose-adjusted trough cyclosporine concentrations significantly increased from day 7 to day 30.
  • Early cyclosporine exposure parameters (day 4) were significantly lower than at later time points (months 2, 3, 6).
  • Only 30% of patients achieved target concentrations with initial dosing at day 3.

Conclusions:

  • Significant time-dependent increases in cyclosporine exposure occur within the first month post-kidney transplantation.
  • Higher initial doses and more frequent dose adjustments are needed early post-transplant due to low bioavailability.
  • C2 monitoring demonstrated a strong correlation with AUC, suggesting its utility in guiding therapy.