A case series of ziprasidone overdoses
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Updated: Sep 26, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Sean M Bryant1, Jeff Zilberstein, Kirk L Cumpston
1Toxikon Consortium/Cook County Hospital, Section of Toxicology, Suite 500, 1900 West Polk Street, Chicago, IL 60612, USA.
Abstract:
In recent years, prescriptions for atypical antipsychotic medications have surpassed traditional antipsychotic agents because of improved treatment of the negative symptoms associated with schizophrenia and a relatively safer side effect profile. The relatively new atypical antipsychotic agent ziprasidone has become a popular treatment for schizophrenia, and like other psychiatric medications has potential for misuse. This series reports 3 cases of ziprasidone overdose. Diligence in cardiac monitoring and obtaining a history of possible co-ingestion are vital in the management of these patients.
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