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Updated: Sep 26, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
Guanidinium rich peptide transporters and drug delivery
Lee R Wright1, Jonathan B Rothbard, Paul A Wender
1Department of Chemistry, Stanford University, Stanford, California 95304, USA.
Abstract:
The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variation and use of guanidinium based transporters to facilitate the uptake of various types of molecules into cells and tissues. Lead conjugates in this area are currently in clinical trials.
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