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Updated: Aug 19, 2026

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
Next-generation materials for nucleic acid delivery
Roy van der Meel1,2, Paul A Wender3,4, Olivia M Merkel5,6,7,8
1Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
None:
Efficient and targeted delivery of nucleic acids is critical for realizing the full therapeutic potential of gene editing, vaccines and RNA-based drugs, and emerging delivery platforms offer innovative solutions through their diverse architectures, tunable properties and distinct biological interactions. In this Viewpoint, researchers working across different delivery platforms - including lipid nanoparticles, synthetic polymers, peptide amphiphiles, coacervate microdroplets, DNA nanostructures and extracellular vesicles - discuss the most promising directions and the main challenges in shaping the future of nucleic acid delivery.
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