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Updated: Aug 7, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
Published on: May 8, 2015
Earrings and padlocks for the double helix: topological labeling of duplex DNA
1Center for Advanced Biotechnology, Boston University, 36 Cummington Street, Boston, MA 02215, USA. vvd@bu.edu
Abstract:
Concatenation of hybridization probe with DNA target is crucial for highly localized detection of targeted sequences and might also be used in various gene-therapy applications. Several approaches based on the attachment of a circular oligonucleotide to designated DNA sites have been proposed. Recently, earring-like probes provide a true topological linkage between a probe and the target, thus allowing the DNA labeling by essentially immobile tags. The latest development in this direction takes advantage of oligonucleotide uptake by supercoiled DNA and is an important step forward.
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